Experimental Arteriosclerosis Using Chicken Model

Experimental Arteriosclerosis

Arteriosclerotic lesions have been produced in monkeys (Macaca nemestrina) by selective removal of the vascular endothelium with an intra-arterial balloon catheter. Immediately after de-endothelialization a platelet layer covers the denuded area. This thrombus is gradually removed and by 7 days the vessel appears to be largely reendothelialized. Beginning at day 4, smooth muscle cells undergo m...

Effect of choline upon experimental canine arteriosclerosis.

Studies have been made of the effect of excess dietary choline upon the arteriosclerosis produced in dogs by a regimen of cholesterol and thiouracil feeding. The choline-fed animals did not differ significantly from the control animals with respect to serum lipid levels, degree of lipid infiltration of their livers or severity of arteriosclerotic involvement. C HOLINE is currently being promote...

Role of vasoconstriction in experimental arteriosclerosis.

• The peculiarities of human arterio-atheroselerosis, its morphology, anatomical distribution, and variation with age, sex, diet, and social conditions, have made agreement difficult concerning its etiology. Observations in clinical medicine and in the laboratory suggest a relationship between vasoconstriction and arteriopathies. Essential hypertension, a disease of small arteries and arteriole...

Chronic rejection in rat aortic allografts. An experimental model for transplant arteriosclerosis.

Chronic rejection has several histological appearances, depending on the type of organ graft. Common to all of them is transplant arteriosclerosis associated with an ongoing inflammatory response in the transplanted graft. To the contrary of classical atherosclerosis, in which the manifestations are mostly focal, proximal, and asymmetric, transplant arteriosclerosis is generalized, and the inti...

Chicken Model